Bipolar affective disorders linked to DNA markers on chromosome 11

Nature. 1987 Feb 26-Mar 4;325(6107):783-7. doi: 10.1038/325783a0.

Abstract

An analysis of the segregation of restriction fragment length polymorphisms in an Old Order Amish pedigree has made it possible to localize a dominant gene conferring a strong predisposition to manic depressive disease to the tip of the short arm of chromosome 11.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Bipolar Disorder / epidemiology
  • Bipolar Disorder / ethnology
  • Bipolar Disorder / genetics*
  • Christianity
  • Chromosomes, Human, Pair 11*
  • DNA / genetics
  • Ethnic Groups
  • Genetic Markers*
  • Humans
  • Pedigree
  • Pennsylvania
  • Polymorphism, Restriction Fragment Length
  • Religion and Medicine

Substances

  • Genetic Markers
  • DNA