A Rogue Foxp3 Mutant Undermines Treg Cell Function

Immunity. 2017 Aug 15;47(2):211-214. doi: 10.1016/j.immuni.2017.07.024.

Abstract

Hayatsu et al. (2017) reveal that a FOXP3 mutant found in some patients afflicted with the autoimmune disease IPEX has broadened DNA-recognition specificity, directly repressing the expression of the gene encoding the transcription factor Batf. Their findings identify Batf as critical to tissue regulatory T cell function and suggest that polymorphisms that impact FOXP3 DNA-binding specificity may contribute susceptibility to autoimmune disease.

Publication types

  • Comment

MeSH terms

  • Autoimmune Diseases / immunology
  • Forkhead Transcription Factors / genetics*
  • Humans
  • T-Lymphocytes, Regulatory / immunology*

Substances

  • Forkhead Transcription Factors