Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression

Gut. 2018 Aug;67(8):1555-1557. doi: 10.1136/gutjnl-2017-314759. Epub 2017 Aug 16.

Authors

Bruce R Stevens^{1

2}, Ruby Goel¹, Kim Seungbum¹, Elaine M Richards¹, Richard C Holbert², Carl J Pepine³, Mohan K Raizada¹

Affiliations

¹ Department of Physiology & Functional Genomics, University of Florida College of Medicine, Gainesville, Florida, USA.
² Department of Psychiatry, University of Florida College of Medicine, Gainesville, Florida, USA.
³ Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.

No abstract available

Keywords: bacterial enterotoxin; brain/gut interactions; enteric bacterial microflora; intestinal barrier function; psychosomatic medicine.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Anxiety
Biomarkers
Cholera Toxin
Depression*
Fatty Acid-Binding Proteins
Gastrointestinal Microbiome*
Haptoglobins
Humans
Intestines
Permeability
Protein Precursors

Substances

Biomarkers
FABP2 protein, human
Fatty Acid-Binding Proteins
Haptoglobins
Protein Precursors
zonulin
Cholera Toxin

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