Cardiometabolic Features of Polycystic Ovary Syndrome: Role of Androgens

Licy L Yanes Cardozo; Damian G Romero; Jane F Reckelhoff

doi:10.1152/physiol.00030.2016

Cardiometabolic Features of Polycystic Ovary Syndrome: Role of Androgens

Physiology (Bethesda). 2017 Sep;32(5):357-366. doi: 10.1152/physiol.00030.2016.

Authors

Licy L Yanes Cardozo^{1

2

3

4}, Damian G Romero^{5

6

4}, Jane F Reckelhoff^{2

6

6

4}

Affiliations

¹ Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi; lyanes@umc.edu dromero@umc.edu.
² Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
³ Women's Health Research Center, University of Mississippi Medical Center, Jackson, Mississippi; and.
⁴ Cardio Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi.
⁵ Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi; lyanes@umc.edu dromero@umc.edu.
⁶ Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi.

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects reproductive-age women. Hyperandrogenemia is present in a significant fraction (~80%) of women with PCOS. Increased prevalence of cardiometabolic risk factors is frequently observed in PCOS women. The present review aims to highlight the key role of androgens in mediating the negative cardiometabolic profile observed in PCOS women.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Androgens / metabolism*
Female
Heart / physiopathology
Humans
Hyperandrogenism / metabolism
Myocardium / metabolism
Polycystic Ovary Syndrome / metabolism*

Substances

Androgens

Abstract

Publication types

MeSH terms

Substances

Grants and funding