Secreted products of Fasciola hepatica inhibit the induction of T cell responses that mediate allergy

Parasite Immunol. 2017 Oct;39(10). doi: 10.1111/pim.12460. Epub 2017 Sep 6.

Abstract

There is evidence from epidemiology studies of a negative association between infection with helminth parasites and the development of allergy and asthma. Here, we demonstrate that the excretory/secretory products of the helminth Fasciola hepatica (FHES) protected mice against ovalbumin (OVA)-induced allergic asthma when administered at time of allergen sensitization. FHES reduced the accumulation of mucus, eosinophils and lymphocytes into the airways of allergen-challenged mice. Furthermore, FHES treatment suppressed Th2 responses in the airways. Interestingly, systemic administration of FHES at allergen challenge had no effect on airway inflammation, demonstrating that alum-induced Th2 response is set following initial allergen sensitization. Our findings highlight the immunomodulatory potential of molecules secreted by F. hepatica.

Keywords: Fasciola hepatica; allergy/atopy; asthma; immune modulation.

MeSH terms

  • Alum Compounds
  • Animals
  • Asthma / chemically induced
  • Asthma / immunology*
  • Asthma / prevention & control
  • Eosinophils / immunology
  • Fasciola hepatica / immunology
  • Fasciola hepatica / metabolism*
  • Helminth Proteins / immunology
  • Helminth Proteins / pharmacology*
  • Immunologic Factors / metabolism
  • Immunologic Factors / pharmacology*
  • Mice
  • Mice, Inbred BALB C
  • Ovalbumin / immunology
  • Th2 Cells / immunology*

Substances

  • Alum Compounds
  • Helminth Proteins
  • Immunologic Factors
  • aluminum sulfate
  • Ovalbumin