Cardioprotective Effects of a Phlorotannin Extract Against Doxorubicin-Induced Cardiotoxicity in a Rat Model

J Med Food. 2017 Oct;20(10):944-950. doi: 10.1089/jmf.2017.3919. Epub 2017 Aug 17.


Long-term therapy with doxorubicin (DOX) is associated with high incidence of cumulative and irreversible dilated cardiomyopathy. The goal of this study was to evaluate the cardioprotective effects and safety of a phlorotannin extract from a brown algae Ecklonia cava (Seapolynol™, SPN) against DOX-induced cardiotoxicity in a rat model. A total of 42 rats were divided into six groups: control, low-dose SPN (LDS), high-dose SPN (HDS), DOX, DOX with low-dose SPN (DOX+LDS), and DOX with high-dose SPN (DOX+HDS). Echocardiography was performed at baseline and after 6 weeks. In left ventricular (LV) ejection fraction, DOX and DOX+LDS groups showed significant decreases (P < .001), while LDS, HDS, and DOX+HDS groups showed no significant change compared with control group. In LV mass index, DOX and DOX+LDS groups showed significant increases (P < .001 and P = .013), while LDS, HDS, and DOX+HDS groups showed no significant change compared with control group. In electron microscopy of the LV wall tissue, DOX+HDS group showed markedly less impaired myofibrils and mitochondria compared with both DOX and DOX+LDS groups. On the findings in echocardiography and electron microscopy, 6-week oral administration of SPN was safe and cardioprotective in a DOX-induced rat cardiotoxicity model in a dose-dependent manner.

Keywords: Ecklonia cava; doxorubicin-induced cardiomyopathy; echocardiography; electron microscopy; phlorotannin.

MeSH terms

  • Animals
  • Antineoplastic Agents / adverse effects*
  • Cardiotoxicity / etiology
  • Cardiotoxicity / prevention & control*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Doxorubicin / adverse effects*
  • Heart / drug effects
  • Humans
  • Male
  • Phaeophyceae / chemistry*
  • Plant Extracts / administration & dosage*
  • Protective Agents / administration & dosage*
  • Rats
  • Rats, Sprague-Dawley


  • Antineoplastic Agents
  • Plant Extracts
  • Protective Agents
  • Doxorubicin