Inhibiting Protein Tyrosine Phosphatase 1B to Improve Regenerative Functions of Endothelial Cells

Yuan Wang; Feng Yan; Wenjing Zhang; Shu Pang; Fan Jiang

doi:10.1097/FJC.0000000000000530

Inhibiting Protein Tyrosine Phosphatase 1B to Improve Regenerative Functions of Endothelial Cells

J Cardiovasc Pharmacol. 2018 Feb;71(2):59-64. doi: 10.1097/FJC.0000000000000530.

Authors

Yuan Wang^{1

2}, Feng Yan^{1

2}, Wenjing Zhang¹, Shu Pang¹, Fan Jiang^{1

3}

Affiliations

¹ Department of Physiology and Pathophysiology, School of Basic Medicine, Shandong University, Jinan, China.
² Department of Emergency, Qilu Hospital, Shandong University, Jinan, China.
³ The Key Laboratory of Cardiovascular Remodeling and Function Research (Chinese Ministry of Education and Chinese Ministry of Health) and The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, China.

PMID: 28817487
DOI: 10.1097/FJC.0000000000000530

Abstract

Protein tyrosine phosphatase-1B (PTP1B) is an important negative regulator of insulin receptor- and vascular endothelial growth factor receptor-dependent signalings in endothelial cells. Genetic or pharmacological inhibition of PTP1B has been shown to enhance endothelial cell proliferation and migration and increase nitric oxide production. In vivo, inhibiting PTP1B can reverse endothelial dysfunction, promote angiogenesis, and accelerate wound healing. Intense research is currently continuing in an effort to discover novel selective PTP1B inhibitors, primarily for treating insulin resistance. We propose that these drugs may also represent a new horizon for boosting the regenerative capacities of endothelial cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Angiogenesis Inducing Agents / pharmacology*
Animals
Anti-Obesity Agents / pharmacology
Cell Movement / drug effects
Cell Proliferation / drug effects
Drug Design*
Drug Discovery / methods*
Endothelial Cells / drug effects*
Endothelial Cells / enzymology
Endothelial Cells / pathology
Humans
Hypoglycemic Agents / pharmacology
Neovascularization, Physiologic / drug effects*
Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors*
Protein Tyrosine Phosphatase, Non-Receptor Type 1 / metabolism
Signal Transduction / drug effects
Wound Healing / drug effects*

Substances

Angiogenesis Inducing Agents
Anti-Obesity Agents
Hypoglycemic Agents
PTPN1 protein, human
Protein Tyrosine Phosphatase, Non-Receptor Type 1