A Triad of Crystals Sheds Light on MDGA Interference with Neuroligation

Olivier Thoumine; Pascale Marchot

doi:10.1016/j.neuron.2017.08.001

A Triad of Crystals Sheds Light on MDGA Interference with Neuroligation

Neuron. 2017 Aug 16;95(4):729-732. doi: 10.1016/j.neuron.2017.08.001.

Authors

Olivier Thoumine¹, Pascale Marchot²

Affiliations

¹ Interdisciplinary Institute for Neuroscience, UMR 5297, Centre National de la Recherche Scientifique, University of Bordeaux, 33000 Bordeaux, France. Electronic address: olivier.thoumine@u-bordeaux.fr.
² Centre National de la Recherche Scientifique, Aix-Marseille Université, "Architecture et Fonction des Macromolécules Biologiques" laboratory, Faculté des Sciences de Luminy, 13288 Marseille, France. Electronic address: pascale.marchot@univ-amu.fr.

PMID: 28817794
DOI: 10.1016/j.neuron.2017.08.001

Abstract

Neurexins and neuroligins form trans-synaptic complexes that promote synapse development. In this issue of Neuron, Aricescu and colleagues (Elegheert et al., 2017) complement and strengthen two recent reports by the Kim and Rudenko teams (Kim et al., 2017; Gangwar et al., 2017) to dissect the molecular determinants by which MDGAs challenge the neurexin-neuroligin partnership.

MeSH terms

Activated-Leukocyte Cell Adhesion Molecule / metabolism
Animals
Cell Adhesion Molecules, Neuronal / metabolism
Dansyl Compounds / metabolism*
Galactosamine / analogs & derivatives*
Galactosamine / metabolism
Multiprotein Complexes / metabolism
Synapses / physiology*

Substances

Activated-Leukocyte Cell Adhesion Molecule
Cell Adhesion Molecules, Neuronal
Dansyl Compounds
Multiprotein Complexes
methyl-N-dansylgalactosaminide
Galactosamine