7SK small nuclear RNA, a multifunctional transcriptional regulatory RNA with gene-specific features

Transcription. 2018;9(2):95-101. doi: 10.1080/21541264.2017.1344346. Epub 2017 Oct 4.

Abstract

The 7SK small nuclear RNA is a multifunctional transcriptional regulatory RNA that controls the nuclear activity of the positive transcription elongation factor b (P-TEFb), specifically targets P-TEFb to the promoter regions of selected protein-coding genes and promotes transcription of RNA polymerase II-specific spliceosomal small nuclear RNA genes.

Keywords: 7SK snRNA; 7SK snRNP; P-TEFb; RNA polymerase II pausing; transcription regulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatin / genetics
  • Chromatin / metabolism
  • Humans
  • Positive Transcriptional Elongation Factor B / metabolism*
  • Promoter Regions, Genetic
  • Protein Binding
  • RNA Polymerase II / genetics
  • RNA Polymerase II / metabolism
  • RNA, Small Nuclear / genetics
  • RNA, Small Nuclear / metabolism*
  • Transcriptional Activation*

Substances

  • Chromatin
  • RNA, Small Nuclear
  • Positive Transcriptional Elongation Factor B
  • RNA Polymerase II

Grant support

Our work was supported by grants from la Fondation ARC pour la recherche sur le cancer (to SE), l'Agence Nationale de la Recherche (to T.K.).