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. 2018;9(2):95-101.
doi: 10.1080/21541264.2017.1344346. Epub 2017 Oct 4.

7SK Small Nuclear RNA, a Multifunctional Transcriptional Regulatory RNA With Gene-Specific Features

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7SK Small Nuclear RNA, a Multifunctional Transcriptional Regulatory RNA With Gene-Specific Features

Sylvain Egloff et al. Transcription. .
Free PMC article

Abstract

The 7SK small nuclear RNA is a multifunctional transcriptional regulatory RNA that controls the nuclear activity of the positive transcription elongation factor b (P-TEFb), specifically targets P-TEFb to the promoter regions of selected protein-coding genes and promotes transcription of RNA polymerase II-specific spliceosomal small nuclear RNA genes.

Keywords: 7SK snRNA; 7SK snRNP; P-TEFb; RNA polymerase II pausing; transcription regulation.

Figures

Figure 1.
Figure 1.
Both active and inactive forms of P-TEFb are recruited to their target gene promoters through association with specific transcription factors.
Figure 2.
Figure 2.
The 7SK/HEXIM/P-TEFb snRNP controls transcription of both protein-coding and RNAPII-specific spliceosomal snRNA genes. In response to transcriptional stress, P-TEFb and 7SK core snRNP are released from the 7SK/HEXIM/P-TEFb snRNP. While P-TEFb stimulates transcription of protein-coding genes through releasing promoter-proximal paused RNAPII, a fraction of the free 7SK core snRNP associates with the Little Elongation Complex (LEC) to facilitate snRNA genes transcription.

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Grant support

Our work was supported by grants from la Fondation ARC pour la recherche sur le cancer (to SE), l'Agence Nationale de la Recherche (to T.K.).

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