Understanding Hepatitis C Virus Drug Resistance: Clinical Implications for Current and Future Regimens

Top Antivir Med. Jul/Aug 2017;25(3):103-109.


Viral resistance to direct-acting antiviral drugs may impact their effectiveness during treatment of hepatitis C virus (HCV) infection. Most data on HCV drug resistance concern genotypes 1 and 3. The clinical impact of resistance to HCV nonstructural protein 5A (NS5A) inhibitors and a practical approach to indications and methods for resistance testing are discussed.

MeSH terms

  • Antiviral Agents
  • Drug Resistance, Viral*
  • HIV Infections
  • Hepacivirus
  • Humans
  • Viral Nonstructural Proteins


  • Antiviral Agents
  • Viral Nonstructural Proteins