Principles of Chemical Biology: Iron and CSCs, Histone Acylation sans Enzymes, Eliciting Silent Gene Clusters, and 2'-deoxy-ADPR as a Second Messenger

Cell Chem Biol. 2017 Aug 17;24(8):919-920. doi: 10.1016/j.chembiol.2017.07.016.


This month: Lysosomal iron linked to cell death in cancer stem cells, non-enzymatic catalyst SynCAc for histone acylation, cytotoxins ivermectin and etoposide bring new anti-fungals out of the crypt, and 2'-deoxy-ADPR as second messenger activating TRPM2.

Publication types

  • Introductory Journal Article

MeSH terms

  • Acylation
  • Adenosine Diphosphate Ribose / analogs & derivatives
  • Adenosine Diphosphate Ribose / metabolism
  • Histones / metabolism*
  • Humans
  • Iron / metabolism*
  • Multigene Family
  • Neoplastic Stem Cells / cytology
  • Neoplastic Stem Cells / metabolism
  • Second Messenger Systems / physiology*
  • TRPM Cation Channels / chemistry
  • TRPM Cation Channels / metabolism


  • Histones
  • TRPM Cation Channels
  • TRPM2 protein, human
  • Adenosine Diphosphate Ribose
  • Iron