Predictors of longer-term outcome in the Vienna omega-3 high-risk study

Nilufar Mossaheb; Miriam R Schäfer; Monika Schlögelhofer; Claudia M Klier; Stefan Smesny; Patrick D McGorry; Maximus Berger; G Paul Amminger

doi:10.1016/j.schres.2017.08.010

Predictors of longer-term outcome in the Vienna omega-3 high-risk study

Schizophr Res. 2018 Mar:193:168-172. doi: 10.1016/j.schres.2017.08.010. Epub 2017 Aug 18.

Authors

Nilufar Mossaheb¹, Miriam R Schäfer², Monika Schlögelhofer³, Claudia M Klier⁴, Stefan Smesny⁵, Patrick D McGorry⁶, Maximus Berger⁷, G Paul Amminger⁸

Affiliations

¹ Department of Psychiatry and Psychotherapy, Clinical Division of Social Psychiatry, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: nilufar.mossaheb@meduniwien.ac.at.
² Orygen Youth Health Research Centre, The University of Melbourne, 35 Poplar Road, 3502 Parkville, Melbourne, VIC, Australia. Electronic address: miriam.schaefer@orygen.org.au.
³ Department of Child and Adolescent Psychiatry, Medical University Vienna, Waehringer Guertel 18-10, 1090 Vienna, Austria. Electronic address: monika.schloegelhofer@meduniwien.ac.at.
⁴ Department of Child and Adolescent Medicine, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: claudia.klier@meduniwien.ac.at.
⁵ Department of Psychiatry, University Hospital Jena, Philosophenweg 3, D-07743 Jena, Germany. Electronic address: Stefan.Smesny@med.uni-jena.de.
⁶ Orygen Youth Health Research Centre, The University of Melbourne, 35 Poplar Road, 3502 Parkville, Melbourne, VIC, Australia. Electronic address: pat.mcgorry@orygen.org.au.
⁷ Laboratory of Psychiatric Neuroscience, Australian Institute of Tropical Health and Medicine (AITHM), James Cook University, 1 James Cook Drive, Townsville, QLD 4810, Australia. Electronic address: maximus.berger@jcu.edu.au.
⁸ Orygen Youth Health Research Centre, The University of Melbourne, 35 Poplar Road, 3502 Parkville, Melbourne, VIC, Australia. Electronic address: amminger@unimelb.edu.au.

PMID: 28823721
DOI: 10.1016/j.schres.2017.08.010

Abstract

Longer-term data on ω-3 polyunsaturated fatty acids (PUFA) for prevention of psychosis in (ultra high risk) UHR individuals have initially shown promising results. This analysis aimed to assess clinical predictors of longer-term outcome in UHR individuals treated with ω-3 PUFAs versus placebo. Data derived from an RCT in 81 UHR individuals treated with ω-3 PUFAs versus placebo for 12weeks and follow-up assessment after a median of 6.7years. Baseline GAF, baseline PANSS global score, pre-to-post-intervention change in EPA (Eicosapentaenoic acid) level were significant predictors of transition to psychosis, PANSS negative score and baseline MADRS reached trend-levels. In the final multivariate Cox regression analysis change in EPA levels remained the only significant predictor. Taking into account all other significant predictors, changes in EPA levels were found to be the single most significant predictor for transition to psychosis in a longer term observation of UHR individuals.

Keywords: Fish oil; Outcome; Polyunsaturated fatty acids; Prodrome; Psychosis; Ultra-high risk.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Austria / epidemiology
C-Reactive Protein / metabolism
Chromatography, Gas
Double-Blind Method
Fasting
Fatty Acids, Omega-3 / administration & dosage*
Female
Humans
Longitudinal Studies
Male
Predictive Value of Tests
Psychiatric Status Rating Scales
Psychotic Disorders / epidemiology*
Psychotic Disorders / prevention & control*
Regression Analysis
Thyroid Hormones / blood
Transaminases / metabolism
Treatment Outcome*

Substances

Fatty Acids, Omega-3
Thyroid Hormones
C-Reactive Protein
Transaminases