Mechanisms of Hepatitis B Virus Persistence

Trends Microbiol. 2018 Jan;26(1):33-42. doi: 10.1016/j.tim.2017.07.006. Epub 2017 Aug 16.


Hepatitis B virus (HBV) chronically infects 250 million people worldwide, resulting in nearly one million deaths annually. Studies in recent years have significantly improved our knowledge on the mechanisms of HBV persistence. HBV uses multiple pathways to harness host innate immunity to enhance its replication. It can also take advantage of the developing immune system and the not-yet-stabilized gut microbiota of young children to facilitate its persistence, and use maternal viral e antigen to educate immunity of the offspring to support its persistence after vertical transmission. The knowledge gained from these recent studies paves the way for the development of new therapies for the treatment of chronic HBV infection, which has so far been very challenging.

Keywords: HBV e antigen; age and maternal effects; chronic hepatitis B; interferon immune responses; vertical transmission.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Child
  • Gastrointestinal Microbiome / immunology
  • Hepatitis B e Antigens
  • Hepatitis B virus / genetics
  • Hepatitis B virus / immunology*
  • Hepatitis B virus / pathogenicity
  • Hepatitis B virus / physiology*
  • Hepatitis B, Chronic / therapy
  • Host-Pathogen Interactions / immunology
  • Humans
  • Immunity, Innate*
  • Infectious Disease Transmission, Vertical
  • Life Cycle Stages
  • Maternal Inheritance / immunology
  • Microbiota
  • Viral Load


  • Hepatitis B e Antigens