To investigate the genetic variation in Haemophilus parasuis (HPS) in Sichuan, China, 11 isolates were analyzed based on the outer membrane protein P2 (OMPP2) sequence. Sequence analysis showed that the 11 isolates shared 93.0 to 100% nucleotide homology with 15 reference strains, and the consistency between the 26 strains was 89.0%. The isolates of HPS-1, 2, 4, 5, 6, 7, 8, 10 and 11 had a 69-base deletion from 770 base pairs (bp) to 850 bp, which was infrequent in China. The phylogenetic tree showed that HPS-3 and HPS-8 had closer relationships with European and Japanese strains, but shared 98.7% nucleotide homology with the SW114 Japanese strain.
Keywords: haemophilus parasuis; outer membrane protein; sequence analysis.