Models and detection of spontaneous recurrent seizures in laboratory rodents

Zool Res. 2017 Jul 18;38(4):171-179. doi: 10.24272/j.issn.2095-8137.2017.042.

Abstract

Epilepsy, characterized by spontaneous recurrent seizures (SRS), is a serious and common neurological disorder afflicting an estimated 1% of the population worldwide. Animal experiments, especially those utilizing small laboratory rodents, remain essential to understanding the fundamental mechanisms underlying epilepsy and to prevent, diagnose, and treat this disease. While much attention has been focused on epileptogenesis in animal models of epilepsy, there is little discussion on SRS, the hallmark of epilepsy. This is in part due to the technical difficulties of rigorous SRS detection. In this review, we comprehensively summarize both genetic and acquired models of SRS and discuss the methodology used to monitor and detect SRS in mice and rats.

Keywords: Animal model; Epilepsy; Spontaneous recurrent seizures.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Epilepsy / diagnosis
  • Epilepsy / genetics
  • Epilepsy / pathology*
  • Gene Expression Regulation
  • Genetic Predisposition to Disease
  • Rodentia

Grant support

This study was supported by the American Epilepsy Society Fellowship (2016)