The Effects of Cortical Hypometabolism and Hippocampal Atrophy on Clinical Trajectories in Mild Cognitive Impairment with Suspected Non-Alzheimer's Pathology: A Brief Report

J Alzheimers Dis. 2017;60(2):341-347. doi: 10.3233/JAD-170098.


The clinical and structural trajectories of suspected non-Alzheimer' pathology (SNAP) remain elusive due to its heterogeneous etiology. Baseline and longitudinal clinical (global cognition, daily functioning, symptoms of dementia, and learning memory) and hippocampal volume trajectories over two years were compared between patients with amnestic mild cognitive impairment (aMCI) with SNAP with reduced hippocampal volumes (SNAP+HIPPO) and aMCI patients with SNAP without reduced hippocampal volumes. SNAP+HIPPO showed overall worse baseline cognitive functions. Longitudinally, SNAP+HIPPO showed faster deterioration of clinical symptoms of dementia. Having both hippocampal atrophy and cortical hypometabolism without amyloid pathology may exacerbate symptoms of dementia in aMCI.

Keywords: Functional decline; hippocampus; mild cognitive impairment; suspected non-Alzheimer’s pathology.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Amyloid / metabolism
  • Atrophy / etiology
  • Atrophy / pathology
  • Cerebral Cortex / diagnostic imaging
  • Cerebral Cortex / metabolism*
  • Cognitive Dysfunction / complications*
  • Cognitive Dysfunction / diagnostic imaging
  • Cognitive Dysfunction / pathology*
  • Female
  • Hippocampus / diagnostic imaging
  • Hippocampus / pathology*
  • Humans
  • Longitudinal Studies
  • Male
  • Metabolic Diseases / diagnostic imaging
  • Metabolic Diseases / etiology*
  • Metabolic Diseases / pathology
  • Models, Statistical
  • Positron-Emission Tomography


  • Amyloid