Topical propolis improves wound healing in patients with diabetic foot ulcer: a randomized controlled trial

Nat Prod Res. 2018 Sep;32(17):2096-2099. doi: 10.1080/14786419.2017.1363755. Epub 2017 Aug 22.


In this randomized controlled trial, diabetic patients with foot ulcers (Wagner grades 1 and 2) were randomly assigned to conventional therapies for diabetic foot ulcer plus topical propolis ointment (5%; twice daily) or conventional therapies alone. The process of ulcer healing was observed during 4 weeks and compared between the two groups regarding the size, erythema, exudates, white blood cell (WBC) count and erythrocyte sedimentation rate (ESR). The process of ulcer size reduction during the four-week period of study was significantly different between the groups. However, this difference was not significant between the third and fourth weeks. There was no significant difference between two groups regarding erythema and exudate reduction as well as WBC count and ESR. Administration of topical propolis ointment in addition to the conventional treatments of diabetic foot ulcer could reduce the size of ulcers with Wagner grades 1 and 2.

Keywords: Propolis; diabetic foot; erythema; ulcer; wound healing.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Diabetic Foot / drug therapy*
  • Diabetic Foot / pathology
  • Erythema / drug therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Propolis / administration & dosage
  • Propolis / pharmacology
  • Propolis / therapeutic use*
  • Time Factors
  • Ulcer / drug therapy
  • Wound Healing / drug effects*


  • Propolis