Environmental endocrine disruptors: New diabetogens?

C R Biol. Sep-Oct 2017;340(9-10):446-452. doi: 10.1016/j.crvi.2017.07.003. Epub 2017 Aug 18.

Abstract

The prevalence of type-2 diabetes has dramatically increased worldwide during the last few decades. While lifestyle factors (sedentariness, noxious food), together with genetic susceptibility, are well-known actors, there is accumulating evidence suggesting that endocrine disrupting chemicals (EDCs) may also play a pathophysiological role in the occurrence of metabolic diseases. Both experimental and epidemiological evidence support a role for early and chronic exposure to low doses of chemical pollutants with endocrine and metabolic disrupting effects. Most are present in the food chain and accumulate in the fat mass after absorption. In rodents, bisphenol A stimulates synthesis and secretion of pancreatic β cells and disturbs insulin signaling in liver, muscle and adipose tissue through epigenetic changes leading to insulin resistance and β cell impairment. In humans, epidemiological reports show statistical link between exposure to pesticides, polychlorinated bisphenyls, bisphenol A, phthalates, dioxins or aromatic polycyclic hydrocarbides or heavy metals and DT2 after acute accidental releases or early in life and/or chronic, low doses exposure. More prospective, longitudinal studies are needed to determine the importance of such environmental risk factors.

Keywords: Chemical pollutants; Diabète de type 2; Endocrine disruptors; Fetal programing; Obesity; Obésité; Perturbateurs endocriniens; Polluants chimiques; Programmation fœtale; Type-2 diabetes; Xenoestrogens; Xénœstrogènes.

MeSH terms

  • Benzhydryl Compounds / toxicity
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / etiology*
  • Endocrine Disruptors / toxicity*
  • Environmental Pollutants / toxicity*
  • Humans
  • Insulin Resistance
  • Pesticides / toxicity
  • Phenols / toxicity
  • Phthalic Acids / toxicity

Substances

  • Benzhydryl Compounds
  • Endocrine Disruptors
  • Environmental Pollutants
  • Pesticides
  • Phenols
  • Phthalic Acids
  • phthalic acid
  • bisphenol A