Distinct topographical localisation of two somatostatin receptor subpopulations in the human cortex

Brain Res. 1987 Mar 17;406(1-2):391-6. doi: 10.1016/0006-8993(87)90813-4.

Abstract

The use of two different radioligands, [125I]Leu8, D-Tryp22,Tyr25-somatostatin-28 and the stable somatostatin octapeptide analog [125I]204-090, D-Phe-Cys[125I]Tyr-D-Trp-Lys-Thr-Cys-Thr(ol), allowed to differentiate between two somatostatin receptor subpopulations in the human cortex. In homogenates, octapeptide somatostatin analogs displaced only part of the somatostatin-28 radioligand with high affinity. Autoradiography showed that the receptor subpopulation labelled with [125I]204-090, which we named SS1, was preferentially localized in layers V and VI, whereas the subpopulation having low affinity for somatostatin octapeptides (named SS2), measured with somatostatin-28 radioligand, was concentrated in the superficial cortical layers (I-IV) and particularly enriched in parts of lamina IV.

MeSH terms

  • Aged
  • Autoradiography
  • Cerebral Cortex / metabolism*
  • Humans
  • Ligands
  • Middle Aged
  • Octreotide
  • Peptide Fragments / metabolism
  • Receptors, Neurotransmitter / metabolism*
  • Receptors, Somatostatin
  • Somatostatin / analogs & derivatives
  • Somatostatin / metabolism
  • Somatostatin-28 / analogs & derivatives

Substances

  • Ligands
  • Peptide Fragments
  • Receptors, Neurotransmitter
  • Receptors, Somatostatin
  • Somatostatin
  • Somatostatin-28
  • somatostatin 28, Leu(8)-Trp(22)-iodo-Tyr(25)-
  • Octreotide