Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 36 (12), 2667-2671

Temporal Trends in Prevalence, Incidence, and Mortality for Rheumatoid Arthritis in Quebec, Canada: A Population-Based Study

Affiliations

Temporal Trends in Prevalence, Incidence, and Mortality for Rheumatoid Arthritis in Quebec, Canada: A Population-Based Study

Sonia Jean et al. Clin Rheumatol.

Abstract

Health administrative data are a potentially efficient resource to conduct population-based research and surveillance, including trends in incidence and mortality over time. Our objective was to explore time trends in incidence and mortality for rheumatoid arthritis (RA), as well as estimating period prevalence. Our RA case definition was based on one or more hospitalizations with a RA diagnosis code, or three or more RA physician-billing codes, over 2 years, with at least one RA billing code by a rheumatologist, orthopedic surgeon, or internist. To identify incident cases, a "run-in" period of 5 years (1996-2000) was used to exclude prevalent cases. Crude age and sex-specific incidence rates were calculated (using data from 2001 to 2015), and sex-specific incidence rates were also standardized to the 2001 age structure of the Quebec population. We linked the RA cohort (both prevalent and incident patients) to the vital statistics registry, and standardized mortality rate ratios were generated. Negative binomial regression was used to test for linear change in standardized incidence rates and mortality ratios. The linear trends in standardized incidence rates did not show significant change over the study period. Mortality in RA was significantly higher than the general population and this remained true throughout the study period. Our prevalence estimate suggested 0.8% of the Quebec population may be affected by RA. RA incidence appeared relatively stable, and mortality was substantially higher in RA versus the general population and remained so over the study period. This suggests the need to optimize long-term RA outcomes.

Keywords: Administrative data; Epidemiology; Mortality; Rheumatoid arthritis.

Similar articles

See all similar articles

Cited by 2 PubMed Central articles

References

    1. Arthritis Rheumatol. 2014 Apr;66(4):786-93 - PubMed
    1. Chronic Dis Inj Can. 2014 Nov;34(4):226-35 - PubMed
    1. Mod Rheumatol. 2007;17(4):290-5 - PubMed
    1. Clin Exp Rheumatol. 2005 Sep-Oct;23(5 Suppl 39):S43-52 - PubMed
    1. Rheumatol Int. 2011 Apr;31(4):549-54 - PubMed

LinkOut - more resources

Feedback