Toxicological effects of trichloroethylene exposure on immune disorders

Immunopharmacol Immunotoxicol. 2017 Dec;39(6):305-317. doi: 10.1080/08923973.2017.1364262. Epub 2017 Aug 22.


Trichloroethylene (TCE) is one of the most common ground water contaminants in USA. Even though recent regulation mandates restricted utilization of TCE, its use is not completely prohibited, especially in industrial and manufacturing processes. The risk of TCE on human health is an ongoing field of study and its implications on certain diseases such as cancer has been recognized and well-documented. However, the link between TCE and immune disorders is still an under-studied area. Studies on the risk of TCE on the immune system is usually focused on certain immune class disorders, but consensus on the impact of TCE on the immune system has not been established. This review presents representative work that investigates the effect of TCE on immune disorders and highlights future opportunities. We attempt to provide a broader perspective of the risks of TCE on the immune system and human health.

Keywords: Trichloroethylene; autoimmunity; developmental immunotoxicity; hypersensitivity; immune disorder; immunosupression; neuroimmune system.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Immune System / drug effects*
  • Immune System Diseases / chemically induced*
  • Risk
  • Trichloroethylene / adverse effects*


  • Trichloroethylene