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. 2017 Aug 22;22(8):1391.
doi: 10.3390/molecules22081391.

Antioxidant and Anticancer Activities of Essential Oil from Gannan Navel Orange Peel

Chao Yang  1 , Hui Chen  2 , Hongli Chen  3 , Balian Zhong  4 , Xuzhong Luo  5 , Jiong Chun  6
Affiliations
Free PMC article

Antioxidant and Anticancer Activities of Essential Oil from Gannan Navel Orange Peel

Chao Yang et al. Molecules. .
Free PMC article

Abstract

China is one of the leading producers of citrus in the world. Gannan in Jiangxi Province is the top navel orange producing area in China. In the present study, an essential oil was prepared by cold pressing of Gannan navel orange peel followed by molecular distillation. Its chemical composition was analyzed by GC-MS. Twenty four constituents were identified, representing 97.9% of the total oil. The predominant constituent was limonene (74.6%). The anticancer activities of this orange essential oil, as well as some of its major constituents, were investigated by MTT assay. This essential oil showed a positive effect on the inhibition of the proliferation of a human lung cancer cell line A549 and prostate cancer cell line 22RV-1. Some of the oil constituents displayed high anticancer potential and deserve further study.

Keywords: GC-MS; Gannan navel orange; anticancer; essential oil.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Total ion chromatogram of navel orange essential oil (NOEO).
Figure 2
Figure 2
Effect of different concentrations of NOEO on viability of A549 (a) and 22RV-1 (b). Cytotoxicity was assessed by MTT assay after treatment with NOEO for 24 h, 48 h, and 72 h.
Figure 3
Figure 3
The apoptosis of A549 cells was induced by NOEO. Flow cytometric analysis of Annexin V-FITC/PI-stained A549 cells: (a) Cells not treated with NOEO as a control; (b) Cells treated with 100 μg/mL of NOEO.
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