Optimal Contractile Forces for a Mesenchymal Engine

Dev Cell. 2017 Aug 21;42(4):313-315. doi: 10.1016/j.devcel.2017.08.005.


The cell and molecular mechanisms that cause a smooth epithelium to become topographically patterned during development are poorly understood. In a recent issue of Science, Shyer et al. (2017) show that myosin II contractility drives the smooth dermal mesenchyme into a pattern of surface bumps that triggers epithelial gene expression.

Publication types

  • Comment

MeSH terms

  • Epithelium*
  • Mesoderm*
  • Muscle Contraction
  • Myosin Type II


  • Myosin Type II