Caffeine and Insomnia in People Living With HIV From the Miami Adult Studies on HIV (MASH) Cohort

J Assoc Nurses AIDS Care. Nov-Dec 2017;28(6):897-906. doi: 10.1016/j.jana.2017.07.008. Epub 2017 Jul 31.


We explored the relationship between caffeine consumption, insomnia, and HIV disease progression (CD4+ T cell counts and HIV viral loads). Caffeine intake and insomnia levels were measured using the Modified Caffeine Consumption Questionnaire and the Pittsburgh Insomnia Rating Scale (PIRS) in 130 clinically stable participants who were living with HIV, taking antiretroviral therapy, and recruited from the Miami Adult Studies on HIV cohort. Linear regressions showed that caffeine consumption was significantly and adversely associated with distress score, quality-of-life score, and global PIRS score. Linear regression analyses also showed that global PIRS score was significantly associated with lower CD4+ T cell counts and higher HIV viral loads. Caffeine could have precipitated insomnia in susceptible people living with HIV, which could be detrimental to their disease progression states.

Keywords: CD4+ T cell count; HIV viral load; caffeine; insomnia; people living with HIV.

MeSH terms

  • Adult
  • Aged
  • Antiretroviral Therapy, Highly Active
  • CD4-Positive T-Lymphocytes / drug effects*
  • Caffeine / administration & dosage*
  • Caffeine / pharmacology
  • Cross-Sectional Studies
  • Disease Progression
  • Female
  • Florida
  • HIV Infections / complications*
  • HIV Infections / drug therapy
  • HIV Infections / virology*
  • Humans
  • Male
  • Middle Aged
  • Sleep Initiation and Maintenance Disorders / complications*
  • Surveys and Questionnaires
  • Viral Load / drug effects*


  • Caffeine