T1-/T2-weighted ratio differs in demyelinated cortex in multiple sclerosis

Ann Neurol. 2017 Oct;82(4):635-639. doi: 10.1002/ana.25019. Epub 2017 Sep 21.


Detecting cortical demyelination in patients with multiple sclerosis (MS) is difficult. Using magnetic resonance imaging (MRI), ratio maps of T1-weighted (T1w) and T2-weighted (T2w) images may be sensitive to cortical myelin levels. In this MRI-histological study, postmortem in situ scans were acquired from 6 cadavers with MS on a 3T MRI machine. Immunocytochemistry was used to correlate myelin status and cortical T1w/T2w measures. The results showed that the T1w/T2w values significantly differed between demyelinated and myelinated cortex (p < 0.001). The T1w/T2w ratio maps may be a relatively simple, clinically feasible method to assess cortical demyelination. Ann Neurol 2017;82:635-639.

MeSH terms

  • Aged
  • Cerebral Cortex / diagnostic imaging*
  • Diagnosis
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Multiple Sclerosis / diagnostic imaging*
  • Myelin Proteolipid Protein / metabolism
  • Myelin Sheath / pathology*


  • Myelin Proteolipid Protein