Investigation of subclinical bacteriuria in cats with dermatological disease receiving long-term glucocorticoids and/or ciclosporin

Vet Dermatol. 2018 Feb;29(1):25-e12. doi: 10.1111/vde.12480. Epub 2017 Aug 18.

Abstract

Background: Dogs receiving long-term glucocorticoids or ciclosporin have an increased frequency of bacteriuria. No studies have investigated the frequency of bacteriuria in cats receiving long-term glucocorticoids and/or ciclosporin.

Hypotheses/objectives: To document whether subclinical bacteriuria occurs in cats receiving long-term glucocorticoid and/or ciclosporin for management of chronic disease.

Animals: Thirty two cats treated with parenteral glucocorticoids and/or oral glucocorticoids and/or ciclosporin were included.

Methods: Thirty two cats receiving oral glucocorticoids and/or ciclosporin for at least three months or at least two injections of long-acting glucocorticoids within the preceding six months were evaluated. Thirty four healthy cats were used as a control group. Urinalysis and urine culture was performed on urine samples collected by cystocentesis from each cat.

Results: In the glucocorticoid/ciclosporin group, none of 32 cats had a positive urine culture. In the control group, one of 34 cats had a positive urine culture. There were no statistically significant differences between the urinalyses from either group.

Conclusions and clinical importance: There was no evidence to suggest that administration of long-term glucocorticoids and/or ciclosporin is associated with bacteriuria in cats.

MeSH terms

  • Animals
  • Bacteriuria / chemically induced
  • Bacteriuria / veterinary*
  • Case-Control Studies
  • Cats
  • Cyclosporine / adverse effects
  • Cyclosporine / therapeutic use*
  • Female
  • Glucocorticoids / adverse effects
  • Glucocorticoids / therapeutic use*
  • Male
  • Skin Diseases / drug therapy
  • Skin Diseases / veterinary*

Substances

  • Glucocorticoids
  • Cyclosporine