Clinical and histological responses of human dental pulp to MTA and combined MTA/treated dentin matrix in partial pulpotomy

Aust Endod J. 2018 Apr;44(1):46-53. doi: 10.1111/aej.12217. Epub 2017 Aug 18.

Abstract

The aim of this study was to compare the responses of mineral trioxide aggregate (MTA) and combined MTA/treated dentin matrix (TDM) as direct pulp capping material. In this clinical trial study, 33 intact third molars in 11 healthy volunteers (three molars in each) were included. Partial pulpotomies were performed in a split mouth manner in two of the third molars in each patient randomly and the third tooth had used as TDM source. The coronal dentin was chopped to dentine chips and transformed to TDM using different concentrations of ethylene diamine tetraacetic acid (EDTA) solution. Pulps were directly capped by MTA alone or using a combination layering of MTA/TDM. Following 6-week clinical and radiological evaluations, each tooth was extracted and prepared for histological evaluation. There were no significant differences in the clinical and radiographic responses or in the quality of dentin bridges (P > 0.05). However, the dentin bridge was significantly thicker in MTA/TDM group than MTA group (P = 0.003). Using the combination of MTA/TDM as a pulp-dressing agent may form a thicker dentin bridge compared to MTA alone.

Keywords: Cvek pulpotomy; direct pulp capping agent; mineral trioxide aggregate; partial pulpotomy; treated dentin matrix.

Publication types

  • Comparative Study

MeSH terms

  • Aluminum Compounds / therapeutic use*
  • Calcium Compounds / therapeutic use*
  • Dental Pulp Capping / methods*
  • Dentin, Secondary*
  • Drug Combinations
  • Female
  • Humans
  • Male
  • Oxides / therapeutic use*
  • Pilot Projects
  • Pulpotomy / methods
  • Root Canal Filling Materials / therapeutic use*
  • Sensitivity and Specificity
  • Silicates / therapeutic use*

Substances

  • Aluminum Compounds
  • Calcium Compounds
  • Drug Combinations
  • Oxides
  • Root Canal Filling Materials
  • Silicates
  • mineral trioxide aggregate