High-dose versus low-dose intravenous immunoglobulin in hypogammaglobulinaemia and chronic lung disease

Lancet. 1987 May 9;1(8541):1075-7. doi: 10.1016/s0140-6736(87)90494-6.


In a randomised cross-over study 12 patients with antibody deficiency and chronic lung disease received monthly infusions of either 0.6 g/kg or 0.2 g/kg intravenous immunoglobulin for six months, and were then switched to the alternative dose for a further six months. Although the incidence of infections did not differ greatly in the high-dose and low-dose phases, the frequency of acute infection was substantially reduced in those periods when serum IgG was 500 mg/dl or more. Pulmonary function worsened on the low-dose regimen and improved on the high-dose regimen.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • Agammaglobulinemia / therapy*
  • Child
  • Chronic Disease
  • Clinical Trials as Topic
  • Female
  • Humans
  • Immunoglobulin G / administration & dosage*
  • Infusions, Intravenous
  • Lung Diseases / complications*
  • Lung Diseases / physiopathology
  • Male
  • Middle Aged
  • Respiratory Function Tests


  • Immunoglobulin G