The late sodium current in heart failure: pathophysiology and clinical relevance

Balazs Horvath; Donald M Bers

doi:10.1002/ehf2.12003

The late sodium current in heart failure: pathophysiology and clinical relevance

ESC Heart Fail. 2014 Sep;1(1):26-40. doi: 10.1002/ehf2.12003.

Authors

Balazs Horvath^{1

2}, Donald M Bers³

Affiliations

¹ Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
² Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary.
³ Department of Pharmacology, School of Medicine, University of California, Davis, CA, USA.

PMID: 28834665
DOI: 10.1002/ehf2.12003

Abstract

Large and growing body of data suggest that an increased late sodium current (I_Na,late ) can have a significant pathophysiological role in heart failure and other heart diseases. The first goal of this article is to describe how I_Na,late functions under physiological circumstances. The second goal is to show the wide range of cellular mechanisms that can increase I_Na,late in cardiac disease, and also to describe how the up-regulated I_Na,late contributes to the pathophysiology of heart failure. The final section of the article discusses the possible use of I_Na,late -modifying drugs in heart failure, on the basis of experimental and preclinical data.

Keywords: Heart failure; Late sodium current; Sodium channel.

Publication types

Review