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Clinical Trial
, 1 (8543), 1174-7

Campylobacter Pylori Detected Noninvasively by the 13C-urea Breath Test

Clinical Trial

Campylobacter Pylori Detected Noninvasively by the 13C-urea Breath Test

D Y Graham et al. Lancet.

Abstract

The high endogenous urease activity of Campylobacter pylori was exploited in a non-invasive test for the presence of this organism in the stomach. When 13C-urea was administered orally after a test meal, urea-derived 13CO2 appeared in the respiratory CO2 of infected individuals at a constant rate for greater than 100 min. The test was validated in 26 individuals who underwent both the 13C-urea breath test and endoscopic biopsy of the antral mucosa for culture and histological examination. Each positive breath test proved to be correlated with a positive culture or Warthin-Starry silver stain of a mucosal biopsy specimen, or both.

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