Epstein-Barr Virus LMP1-Mediated Oncogenicity

J Virol. 2017 Oct 13;91(21):e01718-16. doi: 10.1128/JVI.01718-16. Print 2017 Nov 1.


Epstein-Barr virus latent membrane protein 1 (LMP1) is expressed in multiple human malignancies, including nasopharyngeal carcinoma and Hodgkin and immunosuppression-associated lymphomas. LMP1 mimics CD40 signaling to activate multiple growth and survival pathways, in particular, NF-κB. LMP1 has critical roles in Epstein-Barr virus (EBV)-driven B-cell transformation, and its expression causes fatal lymphoproliferative disease in immunosuppressed mice. Here, we review recent developments in studies of LMP1 signaling, LMP1-induced host dependency factors, mouse models of LMP1 lymphomagenesis, and anti-LMP1 immunotherapy approaches.

Keywords: CD40; LMP1; NF-κB; gamma herpesvirus; oncogene; super-enhancer.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / metabolism
  • Cell Transformation, Neoplastic / pathology*
  • Humans
  • Neoplasms / metabolism
  • Neoplasms / pathology*
  • Viral Matrix Proteins / metabolism*


  • EBV-associated membrane antigen, Epstein-Barr virus
  • Viral Matrix Proteins