Triggering Receptor Expressed on Myeloid cells-1: a new player in platelet aggregation

Thromb Haemost. 2017 Aug 30;117(9):1772-1781. doi: 10.1160/TH17-03-0156. Epub 2017 Jul 27.


Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) is an immunoreceptor initially known to be expressed on neutrophils and monocytes/macrophages. TREM-1 acts as an amplifier of the inflammatory response during both infectious and aseptic inflammatory diseases. Another member of the TREM family, The Triggering receptor expressed on myeloid cells Like Transcript-1 (TLT-1) is exclusively expressed in platelets and promotes platelet aggregation. As the gene that encodes for TLT-1 is located in the TREM-1 gene cluster, this prompted us to investigate the expression of TREM-1 on platelets. Here we show that TREM-1 is constitutively expressed in α-granules and mobilised at the membrane upon platelet activation. Pharmacologic inhibition of TREM-1 reduces platelet activation as well as platelet aggregation induced by collagen, ADP, and thrombin in human platelets. Aggregation is similarly impaired in platelets from Trem-1-/- mice. In vivo, TREM-1 inhibition decreases thrombus formation in a carotid artery model of thrombosis and protects mice during pulmonary embolism without excessive bleeding. These findings suggest that TREM-1 inhibition could be useful adducts in antiplatelet therapies.

Keywords: Platelets; TREM-1.

MeSH terms

  • Animals
  • Blood Platelets / drug effects
  • Blood Platelets / metabolism*
  • Disease Models, Animal
  • Genotype
  • Humans
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Peptides / pharmacology
  • Phenotype
  • Platelet Adhesiveness
  • Platelet Aggregation Inhibitors / pharmacology
  • Platelet Aggregation* / drug effects
  • Pulmonary Embolism / blood*
  • Pulmonary Embolism / genetics
  • Pulmonary Embolism / prevention & control
  • Secretory Vesicles / metabolism
  • Thrombosis / blood*
  • Thrombosis / genetics
  • Thrombosis / prevention & control
  • Triggering Receptor Expressed on Myeloid Cells-1 / antagonists & inhibitors
  • Triggering Receptor Expressed on Myeloid Cells-1 / blood*
  • Triggering Receptor Expressed on Myeloid Cells-1 / deficiency
  • Triggering Receptor Expressed on Myeloid Cells-1 / genetics


  • Peptides
  • Platelet Aggregation Inhibitors
  • TREM1 protein, human
  • TREM1 protein, mouse
  • Triggering Receptor Expressed on Myeloid Cells-1