Renal oncocytoma: origin from the collecting duct

Virchows Arch B Cell Pathol Incl Mol Pathol. 1987;52(5):375-87. doi: 10.1007/BF02889979.

Abstract

The histo- and cytogenesis of two cases of renal oncocytoma have been studied by cytomorphological and cytochemical methods. Transitions from collecting ducts into oncocytic tubules were observed at the light and electron microscopic levels. The fine structure of the oncocytes in tubules and tumors is described in detail. Cytochemically, the oncocytic tubules and oncocytomas share many characteristics with the distal nephron, especially the collecting ducts. A striking difference is the enhanced activity of succinic dehydrogenase which corresponds to the increase in the number of mitochondria in oncocytes. All the results suggest that renal oncocytoma originates from the collecting duct.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / pathology*
  • Adenoma / ultrastructure
  • Aged
  • Histocytochemistry
  • Humans
  • Kidney Neoplasms / pathology*
  • Kidney Neoplasms / ultrastructure
  • Kidney Tubules / pathology*
  • Kidney Tubules, Collecting / enzymology
  • Kidney Tubules, Collecting / pathology*
  • Kidney Tubules, Collecting / ultrastructure
  • Male
  • Microscopy, Electron
  • Middle Aged
  • Succinate Dehydrogenase / analysis

Substances

  • Succinate Dehydrogenase