Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors

Am J Hum Genet. 1987 May;40(5):413-20.


A series of gene probes for chromosome 11 has been used to study the genetic events associated with the development of Wilms tumor. Examination of DNA samples from five patients with Wilms tumor in whom the tumors showed loss of chromosome 11 alleles and their parents indicate that alleles lost in the tumors are of maternal origin. These data suggest that the parental derivation of chromosome 11 alleles lost in these Wilms tumors is not random.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles*
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 11*
  • DNA, Neoplasm / genetics
  • Female
  • Genetic Markers
  • Heterozygote
  • Humans
  • Kidney Neoplasms / genetics*
  • Male
  • Nucleic Acid Hybridization
  • Polymorphism, Restriction Fragment Length
  • Wilms Tumor / genetics*


  • DNA, Neoplasm
  • Genetic Markers