Parenteral methotrexate for patients with Crohn's disease: how to develop a high-quality and safe self-administration service

Frontline Gastroenterol. 2012 Jan;3(1):36-38. doi: 10.1136/flgastro-2011-100021. Epub 2011 Nov 16.


Parenteral methotrexate is recommended for patients with Crohn's disease who have failed treatment with thiopurines. There is no good evidence for the use of oral methotrexate, yet patients frequently receive this due to the difficulties associated with prescribing and administering an unlicensed, cytotoxic drug. We present our experience of developing a local service to provide our patients with the option to self-administer parenteral methotrexate in a safe and structured manner at home.

Publication types

  • Review