Human liver cDNA clones encoding proteolipid subunit 9 of the mitochondrial ATPase complex

Biochem Biophys Res Commun. 1987 May 14;144(3):1257-64. doi: 10.1016/0006-291x(87)91446-x.


Clones encoding the proteolipid subunit 9 of the mitochondrial ATPase complex have been isolated from a lambda gt10 library of human liver cDNA sequences, using a probe of Neurospora crassa cDNA encoding subunit 9. From nucleotide sequence analysis it is concluded that the amino acid sequence of mature human subunit 9 is identical to that of its bovine counterpart. By comparing the sequence of two cDNA clones (denoted human 1 and 2) to those of two bovine cDNA clones (denoted P1 and P2) recently described by Gay and Walker (EMBO J. 4, 3519-3524, 1985) it is evident that there are close sequence relationships between human 1 and bovine P1, and between human 2 and bovine P2, although both human clones are truncated at their 5'-ends. Thus, as in bovine cells there appears to be at least two human genes encoding subunit 9.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cattle
  • Cloning, Molecular*
  • DNA / metabolism*
  • Genes
  • Humans
  • Macromolecular Substances
  • Mitochondria, Liver / enzymology*
  • Proteolipids / genetics*
  • Proton-Translocating ATPases / genetics*
  • Sequence Homology, Nucleic Acid


  • Macromolecular Substances
  • Proteolipids
  • DNA
  • Proton-Translocating ATPases

Associated data

  • GENBANK/M16439
  • GENBANK/M16453