An aspect of the organizational principle of the gamma-aminobutyric acidergic system in the cerebral cortex

Brain Res. 1987 Apr 21;409(2):403-8. doi: 10.1016/0006-8993(87)90732-3.

Abstract

The possibility of the colocalization of a Ca2+-binding protein, parvalbumin (PV), with peptides, cholecystokinin (CCK) and somatostatin (SS), all of which are known to be contained gamma-aminobutyric acidergic neurons in the cerebral cortex, was tested in the rat visual cortex by means of immunohistochemistry using the adjacent section technique. No PV immunoreactive (PV-I) neurons showed CCK-like immunoreactivity, and almost none (932 out of 934 PV-I neurons examined) showed SS-like immunoreactivity. These observations suggest that the GABAergic system of the cerebral cortex may consist of some distinct subsystems with different chemical and presumably physiological characteristics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cerebral Cortex / physiology*
  • Immunoenzyme Techniques
  • Male
  • Parvalbumins / metabolism
  • Rats
  • Rats, Inbred Strains
  • Sincalide / metabolism
  • Somatostatin / metabolism
  • Synaptic Transmission
  • Visual Cortex / physiology*
  • gamma-Aminobutyric Acid / physiology*

Substances

  • Parvalbumins
  • Somatostatin
  • gamma-Aminobutyric Acid
  • Sincalide