Role of cardiolipin in stability of integral membrane proteins

Biochimie. 2017 Nov:142:102-111. doi: 10.1016/j.biochi.2017.08.013. Epub 2017 Aug 23.


Cardiolipin (CL) is a unique phospholipid with a dimeric structure having four acyl chains and two phosphate groups found almost exclusively in certain membranes of bacteria and of mitochondria of eukaryotes. CL interacts with numerous proteins and has been implicated in function and stabilization of several integral membrane proteins (IMPs). While both functional and stabilization roles of CL in IMPs has been generally acknowledged, there are, in fact, only limited number of quantitative analysis that support this function of CL. This is likely caused by relatively complex determination of parameters characterizing stability of IMPs and particularly intricate assessment of role of specific phospholipids such as CL in IMPs stability. This review aims to summarize quantitative findings regarding stabilization role of CL in IMPs reported up to now.

Keywords: Delipidation; Kinetic stability; Membrane protein stability; Protein-lipid interaction.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiolipins / metabolism*
  • Humans
  • Membrane Proteins / metabolism*
  • Mitochondria / metabolism
  • Protein Stability


  • Cardiolipins
  • Membrane Proteins