Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study

Clin Nutr. 2018 Oct;37(5):1602-1608. doi: 10.1016/j.clnu.2017.08.006. Epub 2017 Aug 12.


Background & aims: The associations between dietary magnesium intake and stroke and coronary heart disease (CHD) incidences are inconsistent and not established in Asian. We aimed to determine the association between dietary magnesium intake and the risk of stroke and CHD in a Japanese population.

Subjects/methods: We studied 85,293 Japanese subjects by questionnaire at baseline (age 45-74 years, without cardiovascular disease or cancer in 1995 and 1998 for Cohorts I and II, respectively). The participants were followed until the end of 2009 and 2010 in Cohorts I and II, respectively. Dietary magnesium intake was estimated from a self-administered 138-item food-frequency questionnaire.

Results: After 1,305,738 person-years of follow-up, 4110 strokes and 1283 cases of CHD were documented. The multivariable-adjusted hazard ratios (HRs, 95% confidence intervals, 95%CIs) of CHD for the fourth and fifth quintiles of dietary magnesium intake were 0.70 (0.50-0.99) and 0.66 (0.44-0.97) in men (P for trend = 0.036), respectively, and third quintile of dietary magnesium intake was 0.61 (0.39-0.96) in women (P for trend = 0.241), compared with the lowest quintile in men and women. We observed no decreased risks of incident stroke in men or women with higher dietary magnesium intakes.

Conclusions: Higher dietary magnesium intake was associated with a reduced risk of CHD in Japanese men.

Keywords: Coronary heart disease; Dietary magnesium; Population study; Prospective study; Stroke.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cohort Studies
  • Coronary Disease / epidemiology*
  • Coronary Disease / prevention & control
  • Diet Records
  • Diet*
  • Female
  • Humans
  • Japan / epidemiology
  • Magnesium / administration & dosage*
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk Factors
  • Stroke / epidemiology
  • Stroke / prevention & control
  • Surveys and Questionnaires


  • Magnesium