Adipose tissue inflammation in obesity: a metabolic or immune response?

Curr Opin Pharmacol. 2017 Dec;37:35-40. doi: 10.1016/j.coph.2017.08.006. Epub 2017 Aug 24.

Abstract

Adipose tissue is not only a reservoir for energy, but also an immune organ. In the context of obesity, the development of insulin resistance is now recognised to be initiated by inflammation of the adipose tissue. However, the primary events triggering this inflammation are still unclear, as a complex combination of endocrine and immune factors act to regulate this adipose tissue microenvironment. Below we discuss the different factors involved and how they affect the biology of the adipose tissue in obesity.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / immunology*
  • Adipose Tissue / metabolism*
  • Animals
  • Humans
  • Inflammation / immunology
  • Inflammation / metabolism
  • Obesity / immunology*
  • Obesity / metabolism*