Prospective study of radioimmunoassay for antibodies against neutrophil cytoplasm in diagnosis of systemic vasculitis

Lancet. 1987 Jun 20;1(8547):1389-93. doi: 10.1016/s0140-6736(87)90591-5.


The diagnosis and management of Wegener's granulomatosis and microscopic polyarteritis are complicated by the lack of specific diagnostic tests. The diagnostic performance of a solid-phase radioimmunoassay, which detects the autoantibodies against neutrophil cytoplasm present in these disorders, was assessed in a prospective study of patients with suspected vasculitis and/or rapidly progressive nephritis. The assay had a sensitivity and specificity of 96% when carried out in combination with a specific inhibition stage and indirect immunofluorescence staining of alcohol-fixed normal neutrophils.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoantibodies / analysis*
  • Cytoplasm / immunology
  • Granulomatosis with Polyangiitis / diagnosis*
  • Granulomatosis with Polyangiitis / immunology
  • Granulomatosis with Polyangiitis / therapy
  • Humans
  • Neutrophils / immunology*
  • Polyarteritis Nodosa / diagnosis*
  • Polyarteritis Nodosa / immunology
  • Polyarteritis Nodosa / therapy
  • Prospective Studies
  • Radioimmunoassay


  • Autoantibodies