Genetically driven antioxidant capacity in a Caucasian Southeastern European population

Abstract

Previous studies have underlined the function of specific xenobiotic metabolizing phase-I or phase-II enzymes and endogenous antioxidant-related enzymes in the reduction and/or progression of oxidative stress and consequently the incidence of several diseases. In the present study, 10 polymorphic variants (rs4880, rs1799895, rs660339, rs1050450, rs1001179, rs28665122, rs1695, rs1138272, rs1051740 and rs2234922) were investigated in 1132 individuals of a Caucasian Southeastern European population. The frequency distribution of alleles and genotypes was compared to data of European (Northern, Central, Northwestern and Southwestern) and Global populations, extracted from the ensembl genome browser. The allele frequencies in the case of rs1051740 were similar to the frequencies noted in the global population. The majority of the present study allelic polymorphisms showed similar frequency distribution to those of the European or the Global populations (0.88≤OR≤1.14). The rs1051740 polymorphism demonstrated similar to the Global population frequencies (OR=1.09). In conclusion, observed distributions of the polymorphisms studied in the Southeastern population demonstrate a positive impact (rs4880, rs1799895, rs660339, rs28665122) and a negative impact (rs1050450, rs1138272, rs109179, rs1695) against oxidative stress when compared to other population groups.

Keywords: Antioxidant-related enzymes; Genetic polymorphism; Oxidative stress; Southeastern European population; Specific xenobiotic metabolizing phase-I or phase-II enzymes.