Histamine and hepatic glutathione in the mouse

Life Sci. 1987 May 25;40(21):2103-10. doi: 10.1016/0024-3205(87)90104-4.


A number of histamine receptor agonists and antagonists were utilized to study the effects of histamine on hepatocellular reduced glutathione (GSH) concentrations and the potential role of histamine as a mediator of morphine-induced hepatic GSH depression. Administration of histamine, the H1-histamine receptor agonist thiazolylethylamine, the H2-histamine receptor agonist impromidine, or the histamine-releasing substance compound 48/80 resulted in no significant change in hepatic GSH concentrations. The H1-histamine receptor antagonist chlorpheniramine and the H2-histamine receptor antagonist ranitidine were also without significant effect on hepatic GSH and did not antagonize morphine-induced GSH depression. These observations indicate that histamine release following morphine administration does not play a significant role in the subsequent depletion of hepatic GSH.

MeSH terms

  • Animals
  • Drug Interactions
  • Glutathione / metabolism*
  • Histamine / administration & dosage
  • Histamine / pharmacology*
  • Histamine H1 Antagonists / pharmacology
  • Histamine H2 Antagonists / pharmacology
  • Liver / drug effects
  • Liver / metabolism*
  • Liver / ultrastructure
  • Male
  • Mice
  • Mice, Inbred Strains
  • Morphine / administration & dosage
  • Morphine / pharmacology
  • Receptors, Histamine / drug effects
  • Time Factors
  • p-Methoxy-N-methylphenethylamine / pharmacology


  • Histamine H1 Antagonists
  • Histamine H2 Antagonists
  • Receptors, Histamine
  • p-Methoxy-N-methylphenethylamine
  • Morphine
  • Histamine
  • Glutathione