Effects of Taurine on ACE, ACE2 and HSP70 Expression of Hypothalamic-Pituitary-Adrenal Axis in Stress-Induced Hypertensive Rats

Adv Exp Med Biol. 2017;975 Pt 2:871-886. doi: 10.1007/978-94-024-1079-2_69.


The experiment was to elucidate protective mechanism of taurine against stress-induced hypertension. Thirty two male Wistar rats were randomly divided into four groups. Normal control group and stress control group were intragastrically administered saline; β-alanine stress group were fed with β-alanine (200 mg/kg/day) and taurine stress group with taurine (200 mg/kg/day). The hypertensive model was established by giving rats stress for 3 weeks.Results showed that significant expression levels of angiotensin converting enzyme (ACE) in the hypothalamus, pituitary and adrenal were observed in β-alanine stress group and stress control group (P < 0.05), but significant mRNA expression levels of angiotensin-converting enzyme 2 (ACE2) in taurine stress group and normal control group (P < 0.05). All the groups showed no significant differences in HSP70 mRNA expression levels in hypothalamus (P > 0.05), while taurine stress group exhibited the highest HSP70 mRNA expression levels both in pituitary and in adrenal (P < 0.05). It was also found that β-alanine stress group and stress control group had significantly higher protein expression levels of ACE in hypothalamus, pituitary and adrenal (P < 0.05), but significantly lower protein expression of ACE2 compared to taurine stress group and control groups (P < 0.05). The results indicated that taurine regulated the hypothalamus pituitary adrenal (HPA) axis of the renin-angiotensin-aldosterone system (RAAS) by inhibiting ACE gene and protein expressions and promoting ACE2 and HSP70 protein expressions, thereby contributing to the prevention of stress-induced hypertension.

Keywords: Hypertension; Prevention; Rat; Stress.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin-Converting Enzyme 2
  • Animals
  • HSP70 Heat-Shock Proteins / biosynthesis
  • Hypertension / metabolism*
  • Hypertension / physiopathology
  • Hypothalamo-Hypophyseal System / drug effects*
  • Male
  • Peptidyl-Dipeptidase A / biosynthesis
  • Pituitary-Adrenal System / drug effects*
  • Rats
  • Rats, Wistar
  • Stress, Psychological
  • Taurine / pharmacology*


  • HSP70 Heat-Shock Proteins
  • Taurine
  • Peptidyl-Dipeptidase A
  • Ace2 protein, rat
  • Angiotensin-Converting Enzyme 2