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Review
. 2017 Aug 29;9(9):111.
doi: 10.3390/cancers9090111.

Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features

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Free PMC article
Review

Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features

Kentaro Inamura. Cancers (Basel). .
Free PMC article

Abstract

Microphthalmia-associated transcription (MiT) family translocation renal cell carcinoma (tRCC) comprises Xp11 tRCC and t(6;11) RCC. Due to the presence of fusion genes, Xp11 tRCC and t(6;11) RCC are also known as TFE3- and TFEB-rearranged RCC, respectively. TFE3 and TFEB belong to the MiT family, which regulates melanocyte and osteoclast differentiation, and TFE3- and TFEB-rearranged RCC show characteristic clinicopathological and immunohistochemical features. Recent studies identified the fusion partner-dependent clinicopathological and immunohistochemical features in TFE3-rearranged RCC. Furthermore, RCC with chromosome 6p amplification, including TFEB, was identified as a unique subtype of RCC, along with ALK-rearranged RCC. This review summarizes these recent advancements in our tRCC-related knowledge.

Keywords: ALK; TFE3; TFEB; fusion; kidney; renal cell carcinoma; translocation.

Conflict of interest statement

The author declares no conflicts of interest.

Figures

Figure 1
Figure 1
Morphology of MiT family tRCC (Hematoxylin and Eosin staining; scale bar, 100 µm). (A) Xp11 tRCC, (B) t(6;11) RCC (Case 1), (C) t(6;11) RCC (Case 2), and (D) t(6;11) RCC (Case 3).
Figure 2
Figure 2
Immunohistochemistry of MiT family tRCC. (A) TFE3 staining for Xp11 tRCC, (B) TFEB staining for t(6;11) RCC, (C) HMB45 staining for t(6;11) RCC, and (D) Cathepsin K staining for t(6;11) RCC. Scale bar, 100 µm.
Figure 3
Figure 3
Schematic representation of each fusion pattern for three cases (Cases 13) of t(6;11) renal cell carcinoma. bcr: breakpoint cluster region.

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