Making Flavone Thioethers Using Halides and Powdered Sulfur or Na2S2O3

J Org Chem. 2017 Oct 6;82(19):10617-10622. doi: 10.1021/acs.joc.7b01320. Epub 2017 Sep 13.

Abstract

The method for constructing C-S bonds is very important in organic synthesis. Here a new sulfenylation method to generate flavone thioether derivatives was developed by employing aromatic or alkyl halides, S powder and Na2S2O3 as reactants. Good yields of regioselective Calkyl-S and Caryl-S-substituted flavones were generated under relatively environmentally friendly and simple conditions. This method might be potentially applicable to large scale production, and it enriches current sulfenylation methods.

Publication types

  • Research Support, Non-U.S. Gov't