Hybrid localized surface plasmon resonance and quartz crystal microbalance sensor for label free biosensing

Biosens Bioelectron. 2018 Feb 15;100:23-27. doi: 10.1016/j.bios.2017.08.038. Epub 2017 Aug 31.


We report on the design and fabrication of a hybrid sensor that integrates transmission-mode localized surface plasmonic resonance (LSPR) into a quartz crystal microbalance (QCM) for studying biochemical surface reactions. The coupling of LSPR nanostructures and a QCM allows optical spectra and QCM resonant frequency shifts to be recorded simultaneously and analyzed in real time for a given surface adsorption process. This integration simplifies the conventional combination of SPR and QCM and has the potential to be miniaturized for application in point-of-care (POC) diagnostics. The influence of antibody-antigen recognition effect on both the QCM and LSPR has been analyzed and discussed.

Keywords: LSPR; Point-of-care; QCM.

MeSH terms

  • Adsorption
  • Animals
  • Antibodies, Immobilized / chemistry*
  • Equipment Design
  • Immunoassay / instrumentation
  • Immunoglobulin G / analysis*
  • Nanostructures / chemistry
  • Point-of-Care Systems
  • Quartz Crystal Microbalance Techniques / instrumentation*
  • Rabbits
  • Surface Plasmon Resonance / instrumentation*


  • Antibodies, Immobilized
  • Immunoglobulin G