Vascular Endothelial Growth Factor: An Important Molecular Target of Curcumin

Crit Rev Food Sci Nutr. 2019;59(2):299-312. doi: 10.1080/10408398.2017.1366892. Epub 2017 Sep 25.

Abstract

The discovery of Vascular Endothelial Growth Factor (VEGF), the key modulator of angiogenesis, has triggered intensive research on anti-angiogenic therapeutic modalities. Although several clinical studies have validated anti-VEGF therapeutics, with few of them approved by the U.S. Food and Drug Administration (FDA), anti-angiogenic therapy is still in its infancy. Phytochemicals are compounds that have several metabolic and health benefits. Curcumin, the yellow pigment derived from turmeric (Curcuma longa L.) rhizomes, has a wide range of pharmaceutical properties. It has also been shown to inhibit VEGF by several studies. In this review, we elaborate the effect of curcumin on VEGF and angiogenesis and its therapeutic application.

Keywords: Curcumin; age-related macular degeneration; angiogenesis; breast cancer; vascular endothelial growth factor.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents
  • Antineoplastic Agents, Phytogenic
  • Antioxidants
  • Biological Availability
  • Breast Neoplasms / drug therapy
  • Curcumin / pharmacokinetics
  • Curcumin / pharmacology*
  • Humans
  • Macular Degeneration / drug therapy
  • Neovascularization, Pathologic / drug therapy*
  • Neovascularization, Physiologic / drug effects
  • Phytotherapy
  • Receptors, Vascular Endothelial Growth Factor / drug effects
  • Receptors, Vascular Endothelial Growth Factor / physiology
  • Vascular Endothelial Growth Factor A / blood
  • Vascular Endothelial Growth Factor A / drug effects*
  • Vascular Endothelial Growth Factor A / physiology*

Substances

  • Anti-Inflammatory Agents
  • Antineoplastic Agents, Phytogenic
  • Antioxidants
  • Vascular Endothelial Growth Factor A
  • Receptors, Vascular Endothelial Growth Factor
  • Curcumin