Whole Red Grape Juice Reduces Blood Pressure at Rest and Increases Post-exercise Hypotension

J Am Coll Nutr. 2017 Sep-Oct;36(7):533-540. doi: 10.1080/07315724.2017.1331385. Epub 2017 Aug 30.


Objective: The objective of this study was to evaluate the effect of whole red grape juice (juice) on blood pressure (BP) at rest and on the magnitude of post-exercise hypotension (PEH).

Methods: This double-blind, randomized controlled study was performed with 26 individuals with hypertension (40 to 59 years old) who were divided into experimental (n = 14) and control (n = 12) groups. Subsequently, the experimental group was subdivided according to the initial BP values. The subjects performed 2 sessions of aerobic exercise on a treadmill (60 minutes, 60%-85% maximum heart rate), separated by a 28-day period of supplementation with a daily dose of juice (150 ml for men and 100 ml for women) or a control drink. BP was measured before, during, and immediately after each exercise session as well as every 10 minutes during the 60-minute post-exercise recovery period.

Results: The BP at rest did not change in the experimental group, but when this group was subdivided by initial BP, the subjects with controlled initial BP (EGCP) achieved a significant reduction (133.3 ± 5.6 to 114.6 ± 12.2 mmHg, p = 0.02); in contrast, the experimental group with borderline hypertensive BP values (EGBP) did not. Intervention with juice did not modify PEH in the experimental group, but when this group was divided as a function of the initial BP, PEH was potentiated at some times in EGCP.

Conclusions: We conclude that juice promotes a reduction in BP at rest and is also capable of improving PEH in individuals with hypertension, but these effects are dependent on the initial BP values.

Keywords: Hypertension; blood pressure; exercise; grape; post-exercise hypotension.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Blood Pressure / drug effects*
  • Double-Blind Method
  • Exercise / physiology*
  • Female
  • Fruit and Vegetable Juices
  • Fruit*
  • Humans
  • Hypertension / diet therapy*
  • Hypertension / physiopathology
  • Male
  • Middle Aged
  • Plant Preparations / pharmacology
  • Plant Preparations / therapeutic use
  • Post-Exercise Hypotension / diet therapy*
  • Post-Exercise Hypotension / physiopathology
  • Rest / physiology*
  • Treatment Outcome
  • Vitis*


  • Plant Preparations